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These highlights do not include all the information needed to use VYKOURA safely and effectively. See full prescribing information for VYKOURA. VYKOURATM (leucovorin calcium) injection, for intravenous or intramuscular useInitial U.S. Approval: 1952
Medication labelWhy this: Advisory · dailymed-prescription
VYKOURA is indicated for: 1.1 Rescue after high-dose methotrexate (MTX) therapy in adult and pediatric patients. 1.2 Reducing the toxicity of: Methotrexate in adult and pediatric patients with impaired methotrexate elimination or Folic acid antagonists or dihydrofolate reductase (DHFR) inhibitors following an overdose in adult and pediatric patients. 1.3 Treatment of megaloblastic anemias due to folic acid deficiency in adult and pediatric patients when oral therapy is not feasible. 1.4 Treatment of patients with metastatic colorectal cancer in combination with fluorouracil. Limitations of Use VYKOURA is not indicated for pernicious anemia and megaloblastic anemia secondary to the lack of vitamin B12, because of the risk of progression of neurologic manifestations despite hematologic remission.
- generic_name
- leucovorin calcium
- product_names
- leucovorin calcium
- ndc
- 83831-147, 83831-147-05, 83831-148, 83831-148-35, 83831-149, 83831-149-50
- group
- drugs
- license
- us-gov-pd
- attribution
- Courtesy of the National Library of Medicine
- reviewed
- 2026-09-18
- language
- en